Author: Figen _ermet (Turkey)
Co-authors: Özge Yanık, Ferhad Özer, Sibel Demirel, Emin Özmert
Purpose
To compare choroidal characteristics of typical polypoidal choroidal vasculopathy (T-PCV) and polypoidal choroidal neovascularization (P-CNV) cases.
Setting/Venue
A retrospective cross-sectional study
Methods
Thirty-five eyes of 33 PCV cases, proven with indocyanine green angiography (ICGA), were included in this study. The PCV cases were divided into a T-PCV group (n =23) and a P-CNV group (n =12). The total choroidal area (CA), luminal area (LA), and stromal area (SA) were measured with ImageJ software and Niblack threshold method. The CVI, the proportion of the luminal area to the total choroidal area, was assessed. ICGA images were evaluated for anastomoses between vortex vein systems.
Results
The mean age was 71.4 years in T-PCV and 69.8 years in P-CNV groups (p=0.657). T-PCV cases had significantly higher mean subfoveal choroidal thickness (356.0±168.0 vs 267.8±68.7 µm), lumen area (0.647±0.301 vs 0.502±0.122 mm2) and CVI values (73.9±3.7 vs 70.8±4.5%) comparing to P-CNV cases (p=0.036, p=0.052, p=0.039, respectively). Intervortex venous anastomoses was observed in 69.6% of T-PCV eyes and in 50.0% of P-CNV cases (p=0.292). Regarding T-PCV group, in eyes with intervortex venous anastomoses, mean CA (0.986±0.383 vs 0.613±0.290 mm2), and LA (0.734±0.297 vs 0.449±0.212 mm2) values were significantly higher than cases without venous anastomoses (p=0.012, p=0.022, respectively). In P-CNV group, eyes with and without intervortex venous anastomoses did not show significant difference in choroidal measurements (p>0.05).
Conlusions
T-PCV and P-CNV differs especially in terms of choroidal vascular characteristics. The presence of the higher CVI values and higher frequency of intervortex venous anastomoses in T-PCV cases may ensure distinct vascular pathogenesis of these two PCV subgroup.
Financial Disclosure
Lecturer and Consultant of Bayer, Novartis, and Allergan
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