First report about half dose full fluence photodynamic therapy in the treatment for circumscribed choroidal haemangioma: a case series

Author: Dinah Zur (Israel)

Co-authors: David Pérez González, Michaella Goldstein

Purpose

To investigate the efficacy of half dose photodynamic therapy (PDT) in the treatment of circumscribed choroidal hemangioma (CCH). We present 3 cases of CCH treated with half dose full fluence photodynamic therapy (PDT), leading to shrinkage of the lesion, absorption of retinal exudation and improvement in vision.

Setting/Venue

Case Series

Methods

Three patients diagnosed with peripapillary CCH presented due to decreased vision. Clinical and multimodal imaging evaluation revealed. intra-retinal fluid (IRF) and subretinal fluid (SRF) with macular involvement. In all3 cases, half dose PDT treatment was implemented (59J/cm2, 600mW/cm2 for 83 seconds), applying a spot size covering the whole CCH area.

Results

In all 3 cases, shrinkage of the lesion was seen with average tumor hight reduction of 482 microns. Absorption of SRF and IRF were achieved with average reduction of central macular thickness (CMT) of 177microns. These findings were correlated with visual acuity. No adverse events were observed.

Conlusions

This is the first report showing that half dose PDT has the potential to not only decrease retinal fluid, but also cause shrinkage of the CCH lesion itself. Although the use of PDT has been widely reported and used to treat this pathology, to the best of our knowledge, this is the first report of such anatomical improvement using half-dose PDT for CCH, possibly lessening the adverse effects seen with full dose modality.

Financial Disclosure

Novartis, Bayer, Abbvie, Roche - Consultant No conflict of interest related with this paper