Author: Mustafa Dogan (Turkey)
Co-authors: Müberra Akdoğan, Mehmet Cem Sabaner, Hamidu Hamisi Gobeka
To evaluate the impact of caffeinated and decaffeinated coffee consumption on the macular microcirculation in healthy individuals by using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)
This prospective, randomized, single-centered study enrolled healthy individuals who were randomly divided into two groups; a caffeinated coffee consumer group (study group), and age- and sex-matched decaffeinated coffee consumer group (control group).
Vascular densities of superficial capillary plexus (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ) area, FAZ perimeter (PERIM) and vascular density 300 microns around the FAZ (FD-300), as well as outer retinal and choriocapillary flow areas were measured by OCTA. Meanwhile, central macular thickness (CMT), subfoveal choroidal thickness (CT) and optic nerve fiber layer thickness were measured by OCT. Measurements were carried out prior to consumption, and after the consumption at 30 minutes, 1st, 6th and 24th hours. Measured data were analyzed for statistical significance.
Among 48 participants 24 were females and the other 24 were males. Mean age was 23.45 ± 0.92 in the caffeinated coffee consumer group and 22.73 ± 1.13 in the decaffeinated coffee consumer group. Compared to pre-consumption measurements, there were statistically significant reductions in the parafoveal and perifoveal SCP and DCP vascular densities, outer retinal and choriocapillary flow areas and CT during 30 minutes and one hour after the consumption of caffeinated coffee. There was no significant difference, however, in any parameters between consecutive measurements in the decaffeinated coffee consumers (p>0.05).
This study has shown that caffeinated coffee consumption temporarily can leads to a decline in the measurements of parafoveal and perifoveal vascular densities, outer retinal and choriocapillary flow areas as well as in the CT. Lack of these vascular changes after decaffeinated coffee consumption suggests potential resultant vasoactive nature of caffeine.