Author: Ecaterina Pavlovschi (Moldova, Republic of)
Co-authors: Djina Borovic
The aim of the current study was to investigate whether advanced oxidation protein products (AOPPs), recognized as novel markers of oxidative lesions, determined in serum and tear samples, may be used as a single parameter to monitor oxidative stress in patients with hypertensive retinopathy (HR) and to determine whether there is a correlation between their level and the advancement of the disease.
In the research, were enrolled 90 hypertensive patients who came for a consult at the Ovisus Medical Center, Chisinau, Republic of Moldova, in the period 2018-2019 and who, for the first time, were diagnosed with HR, confirmed after a detailed specific ophthalmological investigation.
The subjects were divided into three groups, using the Keith-Wagner-Barker grading system of HR: GI–36 patients; GII–35 patients; GIII–19 patients. AOPPs were assessed in tear and serum samples and the received results were analysed in SPSS Statistics using non-parametric Kruskal-Wallis and Mann-Whitney tests. Correlation analysis was performed using Spearman correlation test with p≤0.05 - statistically significant.
In the serum samples of the patients with HR was determined a tendency to enhance of AOPPs values as HR advanced in grade, (GI vs GIII, +124%, p=0.07). However, AOPPs tear level presented a tendency of reduction (GI vs GIII, -7%, p=0.655). Only, serum AOPPs levels correlate significantly with low power with HR grade (rs=0.243*, p=0.021), meanwhile serum and tear AOPPs levels do not correlate significantly with each other (rs=-0.037, p=0.731).
Our findings suggests that serum AOPPs can serve as an extra biomarker for monitoring oxidative stress levels in HR patients and it is a potent indicator of the disease severity, while the changes of tear AOPPs level being unsignificant, imply that by themselves they cannot be used as a reliable indicator of an excessive OS. Acknowledgements. The authors declare no conflict of interest or any financial interest to disclosure. Research funding: Doctoral grant offered by Ministry of Education, Culture and Research of Republic of Moldova.
The authors declare no conflict of interest or any financial interest to disclosure. Research funding: Doctoral grant offered by Ministry of Education, Culture and Research of Republic of Moldova.