Angiographic changes in early Type-2 DM correlated with FAZ parameters and visual acuity
Author: Mohamed Ahmed (Egypt)
To quantify and correlate microvascular changes, FAZ parameters and visual acuity in patients with early type-2 DM using optical coherence tomography angiography compared to healthy age & gender- matched controls.
Department of Ophthalmology, Minia University, Minia, Egypt
Angiographic changes in patients with type-2 DM (No or early retinopathy) obtained by OCTA AngioVue (RTVue XR Avanti;Optvue Inc.) were correlated with FAZ parameters & LogMAR VA, and compared to age-matched healthy controls using Spearman correlation test. Comparison between VD, LogMAR VA and FAZ values in both groups computed by Mann-Whitney U test.
A significantly worse best corrected visual acuity was found in diabetic eyes than controls (-0.43 ± 0.42, -0.008 ± 0.03, P < 0.001).By OCTA, diabetic eyes showed significantly reduced superficial retinal plexus VD layer of the whole image and para-foveal areas; (P = 0.003, P ≤ 0.001) respectively. CMT had a significant positive moderate correlation with the vessel density of SCP and DCP in the para-foveal area. Correlations were found between VD, FAZ parameters and LogMAR VA.
The early microvascular changes in diabetic patients (type-2) were detected in the FAZ area with micro-aneurysms found in both superficial and deep retinal layers in all patients with higher density in the deep retinal layer. FAZ parameters (Area, Perimetry and Circularity) were negatively correlated with LogMAR VA and positively correlated with vessel density in both para- & perifoveal areas. Correlating those changes together and serial measurements could help to identify biological biomarkers for early disease detection and status monitoring.
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