Author: Simon Dulz
Co-authors: Martin Stephan Spitzer, Christos Skevas
Abstract
Purpose:Postoperative Endophthalmitis is rare, yet serious event and can result in devastating visual outcome. In order to anticipate retinal function in endophthalmitis, we in cooperated the RETeval ERG (LKC Technologies Inc.; USA) prior to endophthalmitis treatment.
Setting:
Single-center, prospective non-internventional case series
Methods:
A total of eleven patients with clinically verified endophthalmitis and consecutive treatment were included into this trial. By using the RETeval ERG (LKC Technologies Inc.,USA) a photopic flicker (3.0 cd*s/m2, 30 cd/m2, 28.3 Hz) and single flash photopic flash (3.0 cd*s/m2, 30 cd/m2, 2 Hz) protocol were applied and b-wave latency measurements were selectively analyzed and correlated to visual acuity gain over time.
Results:
Preoperative best corrected visual acuity (BCVA) in all eleven patients was on average hand motion (range: no light perception to near visual acuity) and was documented with an average of 20/400 at last postoperative visit. ERG flicker and photopic single flash b-wave latency measurements were analyzed in the affected and non-affected eye and the difference (flicker latency: mean: 2.96ms; Standard Deviation (StD): 2.83 ms; photopic single flash latency: mean: 5.67ms; StD: 6.77 ms) between both was used for further statistical analysis. A Spearmann correlation between the visual gain and the difference in latency measurements was analyzed. Significant correlation (r: -,624; p: 0.04) was obtained between the photopic flicker b-wave latency and visual acuity gain.
Conclusion:
The presented pilot study identifies the photopic flicker b-wave latency as a potential biomarker to predict visual outcome after endophthalmitis.
