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Absolute retinal blood flow in healthy eyes and in eyes with retinal vein occlusion

Author: Thibaud Mautuit (France)

Co-authors: Pierre Cunnac, Frederic Truffer, Martial Geiser, Christophe Chiquet

Purpose

To non-invasively measure retinal venous blood flow (RBF) in healthy subjects and patients with retinal venous occlusion (RVO).

Setting/Venue

he prototype named AO-LDV (Adaptive Optics Laser Doppler Velocimeter), which combines a new absolute laser Doppler velocimeter with an adaptive optics fundus camera (rtx1, Imagine Eyes®, Orsay, France), allows for the measurement of absolute RBF as a function of retinal vessel diameters and simultaneous measurement of red blood cell velocity.

Methods

T A total of 15 healthy subjects and six RVO patients were included. For healthy subjects, all the retinal veins in one eye were measured to obtain the total RBF. For RVO patients, only the temporal veins were measured in both eyes.

Results

In healthy subjects, the total RBF was 37.8 ± 6.8 µl/min. Our results suggests an inversely proportional relationship between total RBF and intra-ocular pressure (r = -0.57) or central subretinal thickness (r = -0.48). No significant relationship was found between total RBF and systolic blood pressure, diastolic blood pressure, ocular perfusion pressure, heart rate, or hematocrit. In RVO patients, a decrease in RBF was noted in occluded veins compared with the contralateral healthy eye.

Conlusions

The new AO-LDV prototype allowed RBF to be measured in healthy and RVO patients. The main limitation at this time is the parallax phenomenon, which could be avoided using the optical path of the rtx1 for the LDV part of the system. The prototype was improved with a fixation system for both eyes and a laser projection system to reduce the parallax phenomenon.

Financial Disclosure

Bayer : financial support of this study

Comments

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