Choroidal features in two types of flat irregular pigment epithelial detachment associated with chronic central serous chorioretinopathy: Avascular versus vascularized

Author: Hamid Riazi (Iran, Islamic Republic of)

Co-authors: Hooshang Faghihi, Elias Khalili Pour, Alireza Mahmoudi, Nazanin Ebrahimiadib, Kaveh Fadakar, Fariba Ghassemi

Purpose

To investigate the differences in the choroidal biomarkers between two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes with chronic central serous chorioretinopathy (CSC).

Setting/Venue

This case-control study included treatment naïve patients with chronic CSC who had FIPED, referred to the Retina clinic of Farabi eye hospital, Tehran University of Medical Sciences, Tehran, Iran, between March 2019 and July 2020

Methods

Enhanced depth imaging optical coherence tomography (EDI-OCT) was done in eyes with FIPED correlated to chronic CSC, fellow eyes and also in healthy normal eyes. Eyes with FIPED was classified into two subgroups based on optical coherence tomography angiography (OCTA) findings: vFIPED and aFIPED. Different choroidal biomarkers such as subfoveal choroidal thickness (SFCT), total choroidal area (TCA) and choroidal vascular index (CVI) were compared between the groups

Results

Forty-four eyes from 44 patients with chronic CSC and FIPED along with 20 healthy gender- and age-matched subjects (40 eyes) were included. OCTA identified vascularization in 14 eyes in FIPED group (31.8%). Mean SFCT was higher in FIPED group compared to two other groups (p = 0.005). In comparison to patients with aFIPED, patients with vFIPED had lower SFCT (p=0.003) and higher CVI (p=0.020) based on multivariate analysis.

Conlusions

The significant differences between aFIPEDs and vFIPEDs in terms of choroidal features suggest that these biomarkers can predict the evolution of FIPED in patients with CSC.

Financial Disclosure

No financial relation with any company