Clinical manifestations and imaging characteristics of optic disc pit: A single center case series over 3 decades

Author: Melih Parlak (Germany)

Co-authors: Carolin Elhardt, Dominik Gangkofner, Armin Wolf

Purpose

The purpose of this study was to evaluate the characteristic features, clinical course, and outcome of treatment if given for patients with optic disc pit (ODP).

Setting/Venue

Ulm University Medical School, Department of Ophthalmology

Methods

We retrospectively investigated a consecutive series of patients with a diagnosis of ODP treated between 1993 and 2020 at the Ophthalmology Department of Ulm University. The main outcome measures were age of onset, gender, eye, length of follow-up, location and depth of optic pit, location of subretinal/intraretinal fluid, treatment, visual acuity during presentation and last visit. Patients without optical coherence tomography (OCT) data were excluded.

Results

Twenty-one eyes of 19 patients were included. Mean age during onset was 35 years (2-76 years). Six patients (%31,6) were female while 13 patients (%68,4) were male. Only two patients had bilateral OPD while 17 patients had an unilateral involvement (right eye:5; left eye:12). Multiple ODPs were not observed. Mean depth of the ODP was 568µm (200-1000µm). The ODP extended over 45° in 7 eyes, 90° in 9 eyes , 135° in 2 eyes and 180°in 3 eyes. All eyes except one had a temporally located ODP while one eye had an inferior location. Optic pit maculopathy was associated in 13 eyes (%62). Four eyes with optic pit maculopathy underwent surgical intervention. Among these patients the visual acuity did not vary during follow-up.

Conlusions

In this study, eyes with ODP were observed over a period of up to three decades and almost all eyes demonstrated stable visual acuity. In eyes with surgical intervention the outcomes showed minor changes, and persistent subretinal fluid or retinoschisis was a common occurrence during long term follow-up.

Financial Disclosure

Novartis, Clinical Trial