Exploratory investigation of reticular pseudodrusen in Asian patients

Author: Chang Ki Yoon (Korea, Republic of)

Co-authors: Hyeong Gon Yu, Un Chul Park, Eun Kyoung Lee, Baek Lok Oh

Purpose

1) To investigate the feature of AMD patients having reticular peudodrusen (RPD). 2) 2) To observe the association of RPD with advanced AMD and impact of RPD on visual function

Setting/Venue

Cross sectional study

Methods

Patients having intermediate AMD in any eye were recruited from the patients visiting the clinic. Fundus potography, fundus autofluorescence image, optical coherence tomography (OCT) and OCT angiography (OCTA) were obtained. Visual acuity and microperimetry data were used to assess the visual function. Drusen type was determined in each eye. Participants were divided as to having RPD or not. AMD severity was scored as AREDS severity scale.

Results

Total 626 eyes of 313 patients were recruited. Patients having RPD in any eye was 108 (34.5%). Female was predominant (85%) and average age was 76.5 years. Gender distribution (Female 87.0% vs 83.4%, P = 0.358) and age (average 76.9 vs 76.3, P=0.496) was not different between RPD and non RPD group . Geographic atrophy (GA) was found in 1% of RPD group and 2% of non RPD group (odds ratio 0.4605 (0.0471-2.341)). Choroidal neovascularization (CNV) was observed in 7% of RPD group and 10% of non-RPD group (odds ratio 0.6288 (0.2981-1.2508)) Comparing visual function of intermediate AMD eye, mean retinal sensitivity and visual acuity were not different between RPD and non RPD group. Central retinal sensitivity was significantly lower in RPD group (17.4 ± 5.4 vs 18.0 ± 6.7, P=0.298)

Conlusions

RPD was found in 30% of intermediate AMD. Advanced AMD prevalence including GA and CNV, were not different whether RPD present or not. Central retinal sensitivity was lower in eye having RPD while visual acuity and mean retinal sensitivity was not different.

Financial Disclosure

We have no financial relation with any company.