Author: Murat Gunay (Turkey)
Co-authors: Murat Gunay, Ersagun Tugcugil, Mehmet Kola, Dilek Uzlu, Hidayet Erdol
Purpose
To identify ultra wide field florescein angiographic (UWF – FFA) findings in preterm infants who received intravitreal bevacizumab (IVB) for the treatment of retinopathy of prematurity (ROP).
Setting/Venue
Karadeniz Technical University, Faculty of Medicine, Department of Ophthalmology
Methods
Between January 2020 and January 2021, preterm infants who underwent UWF – FFA imaging following IVB therapy were studied. After obtaining informed consent from parents, UWF – FFA analysis were performed with Optos® California device. Imaging sessions were performed under topical anesthesia. UWF – FFA was performed in the presence of either incomplete retinal vascularization or suspected disease persistence and / or recurrence signs following IVB treatment. Exclusion criteria included, rejection of the procedure by the parents, history of liver and/or renal insufficiency, cardiovascular and/or cerebrovascular disorder. Procedures were done under supervision of a pediatric anesthesiologist. Following monitorization, sodium fluorescein 10 % was injected intravenously at a dose of 0.1 mg/kg body weight followed by an isotonic saline flush. Any complication during UWF – FFA procedure was noted.
Results
Ten infants underwent UWF – FFA analysis during the study. Mean gestational age, birth weight and postmenstrual treatment time were 27.1 weeks, 986 g and 35.4 weeks. Initial UWF – FFA analysis was performed at a mean of 42.3 postmenstrual weeks. UWF – FA images clearly demonstrated nonperfused retinal areas, florescein leakage, macular edema, retinal vascular abnormalities or status of peripheral vascular termini. Some infants received multiple UWF – FFA sessions.
Conlusions
UWF – FA may be an alternative option to assess retinal vascular changes following IVB treatment. Primary advantage of this procedure seems to be applicability with topical anaesthesia without need for general anesthesia in a preterm child. Furthermore, it has fast imaging speed with high resolution images capturing a 200° field of retina.
Financial Disclosure
Authors have no financial relation with any company.
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