Author: Serkan Ozen (Turkey)
Co-authors: Hasan Burhanettin Kaptı
Purpose
To investigate the effect of monthly intra-silicone Aflibercept injections on visual acuity (VA) and anatomical outcomes in eyes with diabetic tractional retinal detachment (RD) repair.
Setting/Venue
This was a single-hospital (Section of Surgical Sciences, Department of Ophthalmology, Faculty of Medicine, Giresun University) , retrospective, case-control study of 10 eyes of 9 patients (study group) and 9 eyes of 9 patients (control group).
Methods
A retrospective evaluation of monthly intravitreal Aflibercept injection treatment that was performed in 10 eyes of 9 patients (study group) who had undergone diabetic tractional RD surgery ( from August 1, 2018 through March 1, 2021) and received silicone oil was done. Intra-silicon injection of Aflibercept was performed intraoperatively and at 1, 2 and 3 months postoperatively. Silicone oil was removed 3 months after surgery in eyes with attached retinas. The main outcome measures were the logarithm of the minimum angle of resolution (logMAR) VA, central macular thickness (CMT), retinal reattachment rate, rate of epiretinal membrane (ERM) formation at 4th month.
Results
The study group was compared to a control group composed of age- and sex-matched controls (9 eyes of 9 patients- from August 1, 2018 through March 1, 2021) who had undergone diabetic tractional RD surgery and were not received intravitreal anti-vascular endothelial growth factor treatment. In the study group, logMAR VA improved from mean 1.88 ± 0.64 to 1.33 ± 0.45, (P =0.04), CMT improved from mean 478.92 ± 205.63 to 293.00 ± 68.8 (P=0.03), retinal reattachment was achieved in 7 of 10 eyes (70%), and ERM formation was observed in 3 of 10 eyes (33%) at 4 months. In the control group, logMAR VA improved from mean 1.52 ± 0.55 to 1.44 ± 0.56, P=0.55), CMT improved from mean 493.12 ± 199.87 to 335.00 ± 89.65 (P=0.6), retinal reattachment was achieved in 6 of 9 eyes (66%), and ERM formation was observed in 3 of 9 eyes (33%) at 4 months. A significant difference was observed in CMT improvement (P=0.03) and final VA (P=0,046), no significant difference in retinal reattachment rate (P= 0.65), or ERM formation (P=0.41) was observed between groups. Ocular adverse events associated with intra-silicone aflibercept injection were not observed.
Conlusions
The outcomes of vitreoretinal surgery using silicone oil for diabetic retinal detachment repair may be improved by monthly injection of intra-silicone aflibercept. Further prospective studies on larger numbers of patients are recommended for clarifying intra-silicone anti-vascular endothelial factor injection efficacy.
Financial Disclosure
none
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