Lens densitometry for assessment and prediction of cataract progression after pars plana vitrectomy with C3F8-gas for retinal detachment

Author: Christos Skevas (Germany)

Co-authors: Spitzer Martin, Schindler Phillip, Mautone Luca

Purpose

Lens opacification is a common complication after pars plana vitrectomy (PPV) and knowing its progression would facilitate consulting patients. This study quantified and predicted the effect of PPV with C3F8-gas on the lens status after surgery in patients of various age and lens densitometry (LD) treated for rhegmatogenous retinal detachment (RRD).

Setting/Venue

Prospective study conducted between March 2018 to March 2020. The study followed the tenets of the Declaration of Helsinki and was approved by the Medical Institutional Review Board of Hamburg

Methods

Data between March 2018 and March 2020 were evaluated retrospectively. The Pentacam® Nucleus Staging mode (PNS) was used to quantify lens opacification. A mixed effect regression model was created that is capable of predicting LD for any time after PPV by using age and baseline LD as dependent factors. Six random patients were excluded from the creation process of the model to test its power afterwards.

Results

34 patients (male 19 [55.9%], female 15 [44.1%]) have matched the inclusion criteria. Average age was 58.5 years (32-77;±4.3), average follow-up was 7.2 months (3,4-23.1;±1,8) and mean baseline LD was 10.9% (8.7%-14.8%;±0.8). Within 6 months after surgery mean LD increased by 0.8% (10.3% → 11.1%) for patients under 50 years of age (n=5) and by 3.1% (11.0%→14.1%) for patients over 50 years of age (n=29). Using the prediction model, LD values for these six previously selected patients closely match the observed data with an average deviation of 1.07%.

Conlusions

Age and baseline LD were enough adequate factors to predict LD at any time in a clinically acceptable way for cases of RRD treated with C3F8-gas. It might be a useful tool for consideration when consulting about cataract surgery

Financial Disclosure

no financila relations

Comments

-