Lyophilized amniotic membrane patch combined with autologous blood covering in the treatment of refractory macular hole

Author: Yong Wei (China)

Co-authors:

Purpose

To observe the effect of lyophilized amniotic membrane patch combined with viscoelastic agent or autologous blood covering in the treatment eyes with refractory macular hole, including unclosed macular hole, high myopia macular hole, large diameter macular hole (> 700um).

Setting/Venue

case-control study

Methods

Fifteen patients with refractory macular hole were performed with 23g or 25g vitreoretinal surgery. After liquid-gas exchange, according to the size of the macular hole, the lyophilized amniotic membrane patch (slightly larger than the macular hole) was selected to cover the surface of the macular hole, then covered with viscoelastic or autologous blood. Air tamponade were performed in all eyes, and all of them were asked to remain in the prone position for 1 weeks after the surgery.

Results

compared with lyophilized amniotic membrane patch combined with viscoelastic covering group, lyophilized amniotic membrane patch combined with autologous blood covering group, had a little amniotic patch deviation, but less amniotic patch shedding after operation. For the refractory macular hole with good amniotic membrane covering position, the macular hole was closed, and the postoperative visual acuity was improved.

Conlusions

Lyophilized amniotic membrane patch combined with autologous blood covering group has proven to be safe and effective of treatment refractory macular hole and the outcome needs further observation.