Multimodal imaging and clinical characteristics of peripapillary choroidal neovascularization in age-related macular degeneration.

Author: Donato Colantuono (France)

Co-authors: Donato Colantuono, Eric Souied, Francesca Amoroso, Vittorio Capuano, Giuseppe Querques, Alexandra Miere

Purpose

To analyze and describe the clinical and imaging characteristics of a series of patients with peripapillary choroidal neovascularization (PPNV) in the context of age-related macular degeneration (AMD) and to investigate a possible relationship between PCN and the pachychoroid disease spectrum (PDS).

Setting/Venue

Case series of patients diagnosed with PPNV in the Department of Ophthalmology of the Centre Hospitalier Intercommunal de Créteil between January 2013 and January 2018 were retrospectively included.

Methods

Multimodal imaging, including OCTA (Plex Elite, Carl Zeiss Meditec, Inc., Dublin, CA) was obtained for all patients. Choroidal thickness (CT) was measured horizontally across the fovea and circumferentially around the temporal side of the disk to study its relationship to neovascularization. PPNV morphology and features were investigated in all cases.

Results

Thirty-five eyes of 26 patients with PPNV were included in this study, of which 32 eyes (91.4%) had a focal or diffuse increase in CT, 35/35 eyes had pachyvessels (100%), 10 eyes of 35 (28.6%) had choroidal vascular hyperpermeability and 34 eyes of 35 (97.1%) showed vessel attenuation of the inner choroid. Twelve out of 35 (34.2%) developped peripapillary aneurismal type 1 neovascularization colocalizing with the PPNV during follow up. OCTA revealed a densly packed high flow network in the ORCC slab in all cases.

Conlusions

Analysis of choroidal structure, previously described in PDS, performed consistently when applied to our PPNV series, thus supporting the hypothesis that PPNV may be a distinct PDS variant.

Financial Disclosure

none