OCT angiography findings in acute vogt-koyanagi-harada desease

Author: Ahmed Arfaoui (Tunisia)

Co-authors: Asma Khallouli, Rahma Saidane, Racem Choura, Dhouha Gouider, Afef Maalej, Riadh Rannen

Purpose

To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) in Vogt-Koyanagi-Harada disease (VKH).

Setting/Venue

Department of Ophthalmology of the Military Hospital of Tunis, Tunisia.

Methods

This is a cross-sectional case-control study. Ten acute VKH cases presented to our department between january 2019 and june 2020 and 20 healthy controls were enrolled in this study. All included subjects underwent a comprehensive clinical assessment. OCT-A was performed using (Optovue RTVue XR Avanti, AngioVue). A 6 mm×6 macular scans with measurement of the foveal avascular zone (FAZ) and vessel densities (VD) in superficial (SCP) ,deep (DCP) capillary plexus and choriocapillaris (CC) were analyzed.

Results

Mean age was 35 ± 6.6 years in the study group and 34 ± 5.4 years in the control group (p=0.24). The sex ratio was 1.15 .Vessel densities in the SCP, DCP and CC in eyes of the acute VKH group were statistically lower than those of healthy control group ( all p <0.01). The FAZ was larger in the VKH group (p=0.04) .In VKH patients, eyes with serous retinal detachment (SRD) had statistically lower mean vascular density in the CC layer than those without SRD ( P<0.01), while no statistically significant differences were found in vascular densities of SCP and DCP layers between SRD and no SRD eyes. A signficant neagtive correlation was found between VD CC and final BCVA (R=-0.51,p<0.035).

Conlusions

OCT A can show circulatory disruption in SCP, DCP and CC in eyes with acute VKH disease. Anomalies found in the CC layer is associated with SRD. Further investigations are necessary to evaluate the clinical implication of these findings

Financial Disclosure

The authors declare no conflict of interest.