Euretina Logo, Links to homepage.
Euretina Logo, Links to homepage.

Peripapillary microvascular changes in Idiopathic Intracranial Hypertension: Quantitative Analysis Using Optical Coherence Tomography Angiography.

Author: El Ouafi Bouazzaoui (Tunisia)

Co-authors: Rahma Saidane, Racem Choura, Asma Khallouli, Ahmed Arfaoui, Afef Maalej, Riadh Rannen

Purpose

To assess the peripapillary microvascular changes in patients with idiopathic intracranial hypertension (IIH) using optical coherence tomography angiography (OCT-A).

Setting/Venue

Department of Ophthalmology of the Military Hospital of Tunis, Tunisia.

Methods

Twenty-four eyes of 12 patients with IIH and 24 eyes of 24 age-matched healthy controls were enrolled in the study. All subjects underwent a comprehensive ocular examination, including measurement of best-corrected visual acuity (BCVA) and a slit-lamp exam of the anterior segment and fundus. Papilledema was graded according to the Frisen scale. OCT-A scans were performed using AngioVue software of the Optovue RTVue XR Avanti. A 4.5 × 4.5 mm images for the Radial Peripapillary Capillaries (RPC) were obtained. Peripapillary Retinal Nerve Fiber Layer (RNFL) thickness, whole image (wi), inside disc (id) and peripapillary (pp) were evaluated in both groups.

Results

The mean age was 35.7 ± 12 years for patients with IIH and 35.9 ± 9 years for the control group (p = 0.89). Only two patients were treated with acetazolamide. BCVA was 20/20 in all subjects. Six patients had bilateral papilledema, two had unilateral papilledema and in 4 patients, the papilledema had resolved. In patients with papilledema, eight had Grade 1, three Grade 2, two Grade 3, and one Grade 4. Ten eyes had no papilledema. There was a statistically significant thickening of the RNFL thickness in the study group compared to heathy controls. Furthermore, there was a significant decrease in all peripapillary vessel densities in IIH patients with papilledema when compared with the control group (P < 0.001). A negative correlation was found between peripapillary VDs and grade of papilledema (R=-0.654, p=0.032). There was no significant association between RNFL and peripapillary VDs (p=0.18).

Conlusions

OCT-A is a non-invasive imaging modality that may be useful to identify peripapillary vascular network changes associated with Idiopathic Intracranial Hypertension. However, further studies are warranted to confirm the mechanism underlying these findings.

Financial Disclosure

The authors declare no conflict of interest.

Comments

-

IMPORTANT INFORMATION

Beware of fraudulent websites, emails and hotel booking offers

www.euretina.org is the only official website of the European Society of Retina Specialists.
 
Please be wary of websites, emails from third-party agencies using similar names, addresses or branding and purporting to represent Euretina.
 
This includes websites or companies offering Congress registration, hotel accommodation or travel services while claiming to be affiliated with Euretina.

Should you use any website other than www.euretina.org, or book accommodation through an unauthorised third-party site, you may be charged significantly more than the official registration fee, your hotel booking may not be valid, and you may not be registered for the event at all.
 
If you have any questions in relation to registration or accommodation for the Congress, these should only be directed to [email protected].