Author: Racem Choura (Tunisia)
Co-authors: Rahma Saidane, Asma Khallouli, Ines Fendouli, Dhouha Gouider, Afef Maalej, Riadh Rannen
Purpose
The purpose of the present study was to evaluate the Central Macular Thickness (CMT), the Retinal Nerve Fiber Layer thickness (RNFL) and the Ganglion Cell Complex thickness (GCC) measured by Spectral Domain Optical Coherence Tomography (SD-OCT) in eyes with idiopathic macular hole (IMH), to compare them with the fellow eyes and to analyze eventual correlations between SD-OCT parameters and the size of IMH.
Setting/Venue
A prospective monocentric cohort study conducted in the Department of Ophthalmology of the Military Hospital of Tunis, Tunisia.
Methods
A prospective, monocentric cohort study, including 39 eyes of 39 patients, was carried out from Februray 2018 to January 2021. Patients who visited the Department of Ophthalmology in the Military Hospital of Tunis and who were diagnosed with unilateral idiopathic macular holes without participating ophthalmic history were included in this study. SD-OCT measurements (CMT, RNFL, GCC) were performed using Optovue RTVue-XR Avanti in affected and fellow eyes. The affected eyes were divided into two groups according to the size of the macular hole (Group A < 400 μm, Group B ≥ 400 μm). A comparative study was conducted regarding SD-OCT parameters in IMH eyes versus fellow eyes, then in Group A versus Group B.
Results
The study included 39 patients (14 males and 25 females). The mean age was 63,5 ± 12,5 years. Groups A and B included 24 eyes and 15 eyes, respectively. The CMT was significantly thicker in affected eyes than in normal eyes (p = 0.009), while the thickness of the GCC was thinner in affected eyes than in normal eyes (p = 0.01). There was no significant difference in the thickness of the RNFL (p = 0.120). CMT, RNFL, and GCC were not significantly different among the two groups A and B (p = 0.236, p = 0.564, p = 0.198, respectively).
Conlusions
We reported a greater CMT and a thinner GCC in eyes with IMH. Average RNFL thickness did not change regarding to IMH. All three parameters were not correlated to the macular hole size. Further multicentric studies are needed to support our findings.
Financial Disclosure
The authors declare no conflict of interest.
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