Subretinal Hyperreflective Material on Structural OCT in nAMD

Author: João Nassaralla (Brazil)

Co-authors: Miguel Amaro, Mario Mota, Teruo Aihara, Angelo Leite, Crisitna Muccioli, Arthur Nassaralla

Purpose

To assess the importance of subretinal hyperreflective material in nAMD visualized on structuralOCT and its response to anti-VEGF treatment.

Setting/Venue

1. Retina, Instituto de Olhos de Goiânia, Goiânia, Goiás, Brazil. 2. Retina, Eye and Laser, Institute of Belém, Belém, Pará, Brazil. 3. Ophthalmology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. 4. Ophthalmology, Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, São Paulo,Brazil. 5. Centro Especializado em Oftalmologia, Pará, Brazil. 6. Instituto da Visao da Paulista, Sao Paulo, São Paulo, Brazil.

Methods

We analyzed eighteen eyes from twenty five subjects with nAMD. These were nAMD consecutivecases and we followed them for up to five years to investigate the incidence of subretinal hyperreflectivematerial during nAMD treatment with ranibizumab and bevacizumab. THe best visual acuity before treatmentranged from 20/40 to 20/100

Results

We found four cases of subretinal hyperreflective material (SHM) on the follow up of the treatedsubjects. Visual acuity had no improvement during the treatment of the the patients affected by the SHM. Twoof the subjects presenting SHM

Conlusions

The appearance of subretinal hyperreflective material on OCT during treatment with anti-vegffor nAMD is possible and suggests worse visual prognosis when compared to patients with no hyperreflectivematerial

Financial Disclosure

Bayer, Novartis, Genon, Ofta, Latinofarma in research about products