Author: Cagri Ilhan (Turkey)
Co-authors: Mehmet Citirik
Purpose
To analyze peripapillary retinal nerve fiber layer (pRNFL) thickness (pRNFLT) alterations in non-glaucomatous eyes with high myopia (HM), and to describe its relationship with some optic disc (OD) morphologic features.
Setting/Venue
University of Health Sciences, Ulucanlar Eye Research and Education Hospital.
Methods
A cross-sectional case control study includes 185 Caucasian subjects with HM and 122 healthy controls. Results of the pRNFLT analysis provided by optical coherence tomography were compared between the HM and control group, and the effects of some morphological features of OD, including tilt, OD radius, and peripapillary chorioretinal atrophy (pCRA) extension, on pRNFLT analysis were investigated.
Results
The mean pRNFL of the HM group was significantly thinner than the control group in the inferior (p <0.001), superior (p <0.001), and nasal (p =0.001) quadrants. In the HM group, the superior quadrant pRNFL was significantly thinner in the tilted OD subgroup compared to the non-tilted OD subgroup (p <0.001). The mean pRNFLT was negatively correlated with pCRA extension in the inferior (r =-0.209 and p =0.020), superior (r =-0.308 and p <0.001), and nasal (r =-0.235 and p =0.008) quadrants. In the no-pCRA subgroup, only superior quadrant pRNFL was significantly thinner than the control group (p <0.001) and the magnitude of alteration was calculated as 7μm. In the pCRA extension ≤1x OD radius subgroup inferior (p <0.001), superior (p <0.001), and nasal (p =0.005) quadrant pRNFL was significantly thinner than the control group and the magnitude of alteration was calculated as 21μm in the inferior quadrant, 23μm in the superior quadrant, and 5μm in the nasal quadrant. Inferior (p <0.001), superior (p <0.001), and nasal (p <0.001) quadrant pRNFL was also significantly thinner in pCRA extension >1x OD radius subgroup than the control group and the magnitude of alteration was 24μm in the inferior quadrant, 40μm in the superior quadrant, and 17μm in the nasal quadrant.
Conlusions
In non-glaucomatous Caucasian subjects with HM, pRNFL is thinner compared to controls in the inferior, superior, and nasal quadrants, and this thinning is negatively correlated with pCRA extension. Superior quadrant pRNFL is also thinner in tilted OD than non-tilted OD. The morphological characteristics of OD give some opportunities to a physician to interpret pRNFLT analysis without requiring other software or automatized device.
Financial Disclosure
none
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