• Events
    • EURETINA 2023 Amsterdam
      • Information
      • Programme
      • Abstracts
      • Late Breaking
      • Hotels
      • Registration
      • Exhibition Bookings
      • EURETINA Innovation Spotlight (EIS)
    • EURETINA Innovation Spotlight (EIS)
      • Information
      • Programme
      • Contributors
      • Registration
      • Sponsorship
      • Industry Abstracts
    • EURETINA 2023 Vilnius (Winter Meeting)
      • Information
      • Programme
      • Hotels
      • Exhibition Information
      • Abstract Viewer
    • EURETINA 2022 Hamburg
      • On Demand
      • Sustainability Plan
      • Programme Overview
      • Satellite Symposia
      • Exhibitors
      • Abstract Viewer
    • Future Meetings
    • Upcoming Digital Events
  • Free Resources
    • Webinars
    • Podcasts
    • Case Club Cases
    • Abstract Viewer
    • EURETINA Guidelines
    • EURETINA Brief
    • IME ePlatform
  • Membership
  • About
    • EURETINA Board
    • Committees
    • Subspecialty Sections
    • Bye-laws
  • Opportunities
    • EBO-Euretina Exam
    • Mentorship Programme
    • RMCR Grant Programme
    • Observership Grant Programme
    • Women in Retina
      • Seeing is Believing Collection
    • YOURS
    • CME Credits
  • Member Login
Menu
  • Events
    • EURETINA 2023 Amsterdam
      • Information
      • Programme
      • Abstracts
      • Late Breaking
      • Hotels
      • Registration
      • Exhibition Bookings
      • EURETINA Innovation Spotlight (EIS)
    • EURETINA Innovation Spotlight (EIS)
      • Information
      • Programme
      • Contributors
      • Registration
      • Sponsorship
      • Industry Abstracts
    • EURETINA 2023 Vilnius (Winter Meeting)
      • Information
      • Programme
      • Hotels
      • Exhibition Information
      • Abstract Viewer
    • EURETINA 2022 Hamburg
      • On Demand
      • Sustainability Plan
      • Programme Overview
      • Satellite Symposia
      • Exhibitors
      • Abstract Viewer
    • Future Meetings
    • Upcoming Digital Events
  • Free Resources
    • Webinars
    • Podcasts
    • Case Club Cases
    • Abstract Viewer
    • EURETINA Guidelines
    • EURETINA Brief
    • IME ePlatform
  • Membership
  • About
    • EURETINA Board
    • Committees
    • Subspecialty Sections
    • Bye-laws
  • Opportunities
    • EBO-Euretina Exam
    • Mentorship Programme
    • RMCR Grant Programme
    • Observership Grant Programme
    • Women in Retina
      • Seeing is Believing Collection
    • YOURS
    • CME Credits
  • Member Login
  • June 1, 2018
  • Ophthalmologica, Guidelines

Treatment of Macular Degeneration with Sildenafil: Results of a Two-Year Trial

Abstract

Objective: To evaluate PDE5/6 inhibition with sildenafil to reduce choroidal ischemia and treat age-related macular degeneration. 

Methods: Sildenafil was prescribed to treat participants with macular degenerations or macular dystrophies measured by spectral-domain optical coherence tomography, color fundus photography, enhanced depth imaging, and best-corrected visual acuity. 

Results: No change in calcified drusen was noted. Vitelliform-type soft drusen were not substantially changed. A participant with Best vitelliform macular dystrophy had a significant improvement in vision as well as in photoreceptor and ellipsoid layers. 

Conclusions: Our research supports sildenafil as a safe treatment for age-related and vitelliform macular degenerations. Thickened Bruch’s membrane reduces the beneficial effect of perfusion increase, but all eyes appear to benefit from PDE6. Notably, maintenance or improvement in the photoreceptor layer may be the most significant result of sildenafil and is consistent with PDE6 inhibition. Thus, sil­denafil treatment of macular degeneration offers significant potential for vision retention and recovery.

Full Report

Become a member for full Ophthalmologica access

Ophthalmologica is EURETINA’s official journal. As a member, you get full access to the online publication. Apply for a membership today to see more articles like this.

Learn more
PrevPrevious
NextNext

You might also like

Secretariat Address
European Society of Retina Specialists
Ground Floor, The Apex Building 
Blackthorn Road
Sandyford Business Park
Co Dublin, D18 H6K2

Phone:+353 1 2100092
Email: [email protected]

EURETINA 2023 Amsterdam

EURETINA Innovation Spotlight (EIS)

Abstract Viewer

Ophthalmologica

Forum

Opportunities

Memberships

About

Privacy Policy

Contact Us

Newsletter Sign up

By clicking 'Subscribe', you agree to the terms of our Privacy Policy. 
 
 

Follow us

© EURETINA 2022 All rights reserved

  • Events
    • EURETINA 2023 Amsterdam
      • Information
      • Programme
      • Abstracts
      • Late Breaking
      • Hotels
      • Registration
      • Exhibition Bookings
      • EURETINA Innovation Spotlight (EIS)
    • EURETINA Innovation Spotlight (EIS)
      • Information
      • Programme
      • Contributors
      • Registration
      • Sponsorship
      • Industry Abstracts
    • EURETINA 2023 Vilnius (Winter Meeting)
      • Information
      • Programme
      • Hotels
      • Exhibition Information
      • Abstract Viewer
    • EURETINA 2022 Hamburg
      • On Demand
      • Sustainability Plan
      • Programme Overview
      • Satellite Symposia
      • Exhibitors
      • Abstract Viewer
    • Future Meetings
    • Upcoming Digital Events
  • Free Resources
    • Webinars
    • Podcasts
    • Case Club Cases
    • Abstract Viewer
    • EURETINA Guidelines
    • EURETINA Brief
    • IME ePlatform
  • Membership
  • About
    • EURETINA Board
    • Committees
    • Subspecialty Sections
    • Bye-laws
  • Opportunities
    • EBO-Euretina Exam
    • Mentorship Programme
    • RMCR Grant Programme
    • Observership Grant Programme
    • Women in Retina
      • Seeing is Believing Collection
    • YOURS
    • CME Credits
  • Member Login