Author: Irini Chatziralli (Greece)
Co-authors: Dimitrios Kazantzis, Alexandros Chatzirallis, Genovefa Machairoudia, George Theodossiadis, Panagiotis Theodossiadis, Theodoros Sergentanis
Purpose
The purpose of this systematic review and meta-analysis of the literature is to evaluate the association between cardiometabolic risk factors (hypertension, diabetes mellitus, hypercholesterolemia/dyslipidemia, HDL cholesterol, LDL cholesterol, lipoprotein(a) and triglycerides) and non-arteritic anterior ischemic optic neuropathy (NAION).
Setting/Venue
2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece
Methods
Pertinent publications were identified through systematic search in PubMed and EMBASE databases, without language restrictions. The pooled odds ratios (OR) and standardized mean differences (SMD), with their 95% confidence intervals (95% CI) were estimated using random effects (DerSimonian Laird) models, as appropriate. A set of subgroup analyses and meta-regression analysis models were performed.
Results
21 studies (including 1560 patients with NAION and 2292 controls), examining the association between NAION and cardiometabolic risk factors were eligible for the systematic review and meta-analysis. Hypertension (pooled OR= 1.50; 95% CI: 1.16-1.94), diabetes mellitus (pooled OR= 1.71; 95% CI: 1.33-2.21), hypercholesterolemia/dyslipidemia (pooled OR=2.00; 95% CI: 1.53-2.62) were associated with NAION. Among the components of dyslipidemia, higher serum triglycerides were associated with NAION, with a medium effect size (SMD= +0.58, 95% CI: +0.12 to +1.04), whereas synthesis of four studies reporting on HDL and LDL cholesterol did not reveal any significant associations. A significant association between NAION and higher serum lipoprotein(a) levels (pooled OR=2.88; 95%CI: 1.01-8.21) was also noted.
Conlusions
This systematic review and meta-analysis found that NAION was associated with cardiometabolic factors, namely hypertension, diabetes mellitus, dyslipidemia and elevated lipoprotein (a), suggesting that vascular dysfunction may be implicated in the pathogenesis of the disease. Our findings may alert health care providers to pay attention to patients with cardiometabolic factors for visual symptoms indicative of NAION, as well as try to modify these risk factors for the prevention of NAION.
Financial Disclosure
No
Comments
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